Activity-Dependent Transfer of Brain-Derived Neurotrophic Factor to Postsynaptic Neurons
作者： K. Kohara
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摘要: Neurotrophins such as brain-derived neurotrophic factor (BDNF) are thought to be transferred from post- presynaptic neurons and involved in the formation plasticity of neural circuits. However, direct evidence for a transneuronal transfer BDNF its relation neuronal activity remains elusive. We simultaneously injected complementary DNAs green fluorescent protein (GFP)-tagged red fluorescence into nucleus single visualized expression, localization, transport living neurons. Fluorescent puncta representing moved axons anterograde direction, though some retrogradely, postsynaptic an activity-dependent manner.
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Laurie J. Goodman, Janet Valverde, Filip Lim, Michael D. Geschwind, Howard J. Federoff, Alfred I. Geller, Franz Hefti, Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Molecular and Cellular Neuroscience. ,vol. 7, pp. 222- 238 ,(1996) , 10.1006/MCNE.1996.0017
Carla J. Shatz, Impulse activity and the patterning of connections during cns development Neuron. ,vol. 5, pp. 745- 756 ,(1990) , 10.1016/0896-6273(90)90333-B
Tobias Bonhoeffer, Neurotrophins and activity-dependent development of the neocortex Current Opinion in Neurobiology. ,vol. 6, pp. 119- 126 ,(1996) , 10.1016/S0959-4388(96)80017-1
Christopher S. von Bartheld, Margaret R. Byers, Reg Williams, Mark Bothwell, Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system. Nature. ,vol. 379, pp. 830- 833 ,(1996) , 10.1038/379830A0
W. Singer, Development and Plasticity of Cortical Processing Architectures Science. ,vol. 270, pp. 758- 764 ,(1995) , 10.1126/SCIENCE.270.5237.758
R Levi-Montalcini, The nerve growth factor 35 years later Science. ,vol. 237, pp. 1154- 1162 ,(1987) , 10.1126/SCIENCE.3306916
Alessandro Cellerino, Lamberto Maffei, The action of neurotrophins in the development and plasticity of the visual cortex. Progress in Neurobiology. ,vol. 49, pp. 53- 71 ,(1996) , 10.1016/0301-0082(96)00008-1
H. Thoenen, Neurotrophins and neuronal plasticity. Science. ,vol. 270, pp. 593- 598 ,(1995) , 10.1126/SCIENCE.270.5236.593
James P. Fawcett, Shernaz X. Bamji, Carrie G. Causing, Raquel Aloyz, Ariel R. Ase, Tomas A. Reader, John H. McLean, Freda D. Miller, Functional Evidence that BDNF Is an Anterograde Neuronal Trophic Factor in the CNS The Journal of Neuroscience. ,vol. 18, pp. 2808- 2821 ,(1998) , 10.1523/JNEUROSCI.18-08-02808.1998
James M. Conner, Julie C. Lauterborn, Qiao Yan, Christine M. Gall, Silvio Varon, Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport The Journal of Neuroscience. ,vol. 17, pp. 2295- 2313 ,(1997) , 10.1523/JNEUROSCI.17-07-02295.1997