Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.

摘要: Background Hedgehog signaling proteins play important roles in development by controlling growth and patterning various animals including Drosophila mammals. Hedgehog triggers changes responsive cells through a novel transduction mechanism that ultimately controls the transcription of specific target genes via activity zinc finger factors Cubitus interruptus /GLI family. In flies, key signal components have been identified kinesin-related protein Costal2, serinethreonine kinase Fused, PEST-containing Suppressor Fused. These control cleavage, nucleo-cytoplasmic localization activation. fly embryos, Fused are associated at least one cytoplasmic complex, which interacts with microtubules Hedgehog-dependent manner.