Relationship of mortality to increasing oxygen delivery in patients >or=to50 years of age: A prospective, randomized trial

作者: Mihae Yu , Sherry Burchell , Nahidh W.M.A. Hasaniya , Danny M. Takanishi , Sally A. Myers

DOI: 10.1097/00003246-199806000-00018

关键词:

摘要: Objective To investigate the relationship of mortality to early resuscitation using two levels oxygen delivery (DO2) in critically ill surgical patients >or=to50 yrs age who were stratified into groups: 75 (age >75 group). Design A prospective, randomized trial, continued from a previous project. Setting Surgical intensive care unit, university affiliated. Patients Consecutive patients, age, unable generate DO (2) >or=to600 mL/min/m2 with fluid alone, diagnosis systemic inflammatory response syndrome, sepsis, severe septic shock, and/or acute respiratory distress syndrome. Interventions During first 24 hrs resuscitation, receive fluids, blood transfusions, and vasoactive agents order achieve DO2 treatment goals protocol group 450 550 control group. Measurements Main Results One hundred five completed study. In aged 50 yrs, rate was 21% (9/43) 52% (12/23) (p = .01, 95% confidence interval -58% -4%). 57% (12/21) 61% (11/18) Oxygen extraction ratios (O2 ER) consumption values significantly .02) lower compared Conclusions receiving demonstrated statistically significant .01) improved survival over no benefit attempts increase >600 mL/min/m2, they may have been overtreated as reflected by O2 ER this Treating an that reflects balance between be alternative goal allows individual titration. (Crit Care Med 1998; 26:1011-1019)

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