Medical reversal: why we must raise the bar before adopting new technologies.

摘要: Medical reversal occurs when a new clinical trial - superior to predecessors by virtue of better controls, design, size, or endpoints contradicts current practice. In recent years, we have witnessed several instances medical reversal. Famous examples include the class 1C anti-arrhythmics post-myocardial infarction (contradicted CAST trial) routine stenting for stable coronary disease COURAGE trial). this paper, explore phenomenon The causes and consequences are discussed. Conflicts interest among researchers an unyielding faith in basic science explored as root Reversal harms patients who undergo contradicted therapy during years it was favor those lag time before change Most importantly, creates loss system physicians patients. solution is upfront, randomized trials practices systematic method evaluate already existence.