Radiation-related Lymphopenia after Pelvic Nodal Irradiation for Prostate Cancer.

摘要: Abstract Purpose Given the uncertainty with regard to effectiveness of pelvic nodal irradiation (PNI) for prostate cancer, we aimed determine whether patients cancer who are treated PNI at a higher risk developing radiation-related lymphopenia (RRL). Methods and materials The electronic charts 886 consecutive radiation therapy between 2006 2018 our institution were retrospectively analyzed. Qualifying those total lymphocyte counts within 1 year before 3 24 months after start therapy. Lymphopenia was primary outcome, overall survival biochemical progression-free secondary outcomes. Results Thirty-six 95 without qualified inclusion. In cohort, 61.1% developed RRL (median follow-up count  Conclusions among comports other papers that show increased treatment volumes associated rates RRL. Mounting evidence adverse effects on clinical outcomes supports significance findings suggests further studies needed as potential harm may affect interpretation results from trials PNI.