Atheroprotective effects of high-density lipoprotein-associated lysosphingolipids.

摘要: Numerous epidemiological studies document an inverse relationship between plasma high-density lipoprotein (HDL) levels and the extent of atherosclerotic disease. The atheroprotective effects HDL are more often seen in conjunction with ability to restrict proinflammatory processes thereby carry out cytoprotection organoprotection. Lysosphingolipids such as sphingosine 1 phosphate, sphingosylphosphorylcholine, lysosulfatide biologically active compounds that have recently been found be associated particles. An increasing body evidence suggests several anti-inflammatory exerted by can attributed presence lysosphingolipids this fraction. In review, we discuss latest developments concerning potential role HDL-associated lysosphingolipids.