Cardiac Cellular Pharmacology: Automaticity in Cardiac Muscle—Its Alteration by Physical and Chemical Influences

摘要: The heart rhythmically and spontaneously activates itself many times in a minute. process responsible for this behavior has been termed the “normal automatic mechanism” is property of only few cell types heart. Cells sinoatrial node, atrioventricular rings, ventricular specialized conducting tissues possess capacity automaticity type whereas ordinary atrial muscle cells do not. This mechanism not basis normal cardiac rhythmicity but also can generate arrhythmias Although complex probably varies somewhat different species, much now known about membrane which underlies alterations caused by variety physical chemical influences. In chapter, it our intention to discuss factors modify brought spontaneous diastolic depolarization.