Selective verbal recognition memory impairments are associated with atrophy of the language network in non-semantic variants of primary progressive aphasia.

摘要: Primary progressive aphasia (PPA) is clinically defined by an initial loss of language function and preservation other cognitive abilities, including episodic memory. While PPA primarily affects the left-lateralized perisylvian network, some clinical neuropsychological tests suggest concurrent memory loss. The goal this study was to test recognition objects words in visual auditory modality separate language-processing impairments from retentive PPA. Individuals with non-semantic had longer reaction times higher false alarms for word stimuli compared object stimuli. Moreover, were related cortical thickness within left inferior frontal gyrus temporal pole, while right-temporal pole. This pattern results suggests that specific vulnerability processing verbal can hinder PPA, provides evidence differential contributions right poles