Taurine Prevents Tamoxifen‐Induced Mitochondrial Oxidative Damage in Mice

摘要: Tamoxifen is a selective oestrogen receptor modulator widely used in the treatment of breast cancer. potentially affects mitochondrial functions as it acts an uncoupling agent and powerful inhibitor electron transport chain. There concern for deleterious effects tamoxifen. Taurine known to have membrane stabilizing antioxidant properties. We studied effect taurine pre-treatment on toxicity tamoxifen mouse liver mitochondria focusing specifically redox cycle biomarkers. caused significant rise lipid peroxidation, protein carbonyl content superoxide radical generation. was change thiol profile tamoxifen-treated animals. Pre-treatment mice with (100 mg/kg) markedly lowered It also restored decreased enzymatic non-enzymatic antioxidants mitochondria. suggested that has potential role ameliorating tamoxifen-induced toxicity, protection afforded either by reversing decline or direct free radical-scavenging activity.