Serum insulin-like growth factor-1 measurement in the diagnosis and follow-up of patients with acromegaly: preliminary data.

摘要: Measurement of serum insulin-like growth factor-1 (IGF-I) is the current method for diagnosing and monitoring acromegaly. However, use commercially available kits needs to be validated. In our study, we have investigated two different IGF-I immunoassays in patients already diagnosed with We compared a two-site immunoradiometric assay ethanol-acid extraction (IRMA-DSL) solid-phase chemiluminescent immunometric (ICMA-IMMULITE), correlating clinical finding biochemical results. A total 102 samples (77 women 25 men aged 18–79 years) were analyzed assays. Sixty-four had been taken from acromegaly stages. Pearson regression showed high correlation coefficient; otherwise, Bland Altman analyses mean difference 177.6 ng/ml, upper lower limits –183.5 538.7 ng/ml studied. Normal was found 64 41.5% treated when measured by ICMA IRMA, respectively. IGF-I-ICMA better The reevaluation necessary correctly interpret treatment response acromegalic thus achieve between