apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor

摘要: Abstract The major component of senile plaques found in the brains Alzheimer disease patients is beta-amyloid peptide, which derived from a larger amyloid precursor protein (APP). Recently, number APP and APP-related proteins have been identified different organisms constitute family proteins. We isolated several cDNAs encoding an nematode Caenorhabditis elegans designated corresponding gene as apl-1. The apl-1 transcripts undergo two forms posttranscriptional modification: trans-splicing alternative polyadenylylation. In vitro translation cDNA results approximately expected size. Similar to Drosophila, human, mouse proteins, APL-1 does not appear contain peptide. Because seem be conserved through evolution, C. should important for determining normal function human APP.