Progesterone receptor immunoreactivity differs in the uterus of pseudopregnant and medroxyprogesterone acetate-treated rabbits
作者： Santiago R. Anzaldúa Arce , C. Adriana Mendoza-Rodríguez , Ignacio Camacho-Arroyo , Marco Cerbón , Mario Pérez-Martínez
DOI: 10.1016/J.ANIREPROSCI.2010.03.005
关键词:
摘要: Progesterone receptor (PR) plays an important role in mammals pregnancy which is characterized by greater progesterone plasma concentrations. We assessed PR protein distribution the rabbit uterus immunohistochemistry two progestational conditions: pseudopregnancy (intact adult animals treated with hCG) and after application of a synthetic progestin, medroxyprogesterone acetate (MPA), to ovariectomized (OVX). immunoreactivity uterine epithelium pseudopregnant rabbits was increased relation non-pseudopregnant (NP) rabbits. Amounts were similar on Days 1, 3, 5 treatment, Day 7 (P<0.001). In contrast, significant diminution observed stroma cells from 1 OVX MPA, increase reaching maximum 3 stromal when compared group MPA treatment (P<0.001), there slight 5. Results suggest differential time course tissue specific for conditions. The present study indicated progestins have different mechanisms regulation than those natural hormones it should be taken into account reproductive applications.
cabdirect.org
elsevier.com
sci-hub.se 参考文章(36)
HENNING M. BEIER, The Discovery of Uteroglobin and Its Significance for Reproductive Biology and Endocrinology Annals of the New York Academy of Sciences. ,vol. 923, pp. 9- 24 ,(2006) , 10.1111/J.1749-6632.2000.TB05516.X
Arleen L. Sawitzke, William D. Odell, Uterine binding sites for LH/hCG can be modulated by hormonal status in rabbits and rats European Journal of Endocrinology. ,vol. 124, pp. 322- 330 ,(1991) , 10.1530/ACTA.0.1240322
Ruben Gutierrez‐Sagal, Gregorio Perez‐Palacios, Elizabeth Langley, Ana Maria Pasapera, Ivone Castro, Marco Antonio Cerbón, None, Endometrial expression of progesterone receptor and uteroglobin genes during early pregnancy in the rabbit Molecular Reproduction and Development. ,vol. 34, pp. 244- 249 ,(1993) , 10.1002/MRD.1080340303
F. Di Carlo, S. Racca, G. Conti, E. Gallo, G. Muccioli, A. Sapino, G. Bussolati, Effects of long-term administration of high doses of medroxyprogesterone acetate on hormone receptors and target organs in the female rat. Journal of Endocrinology. ,vol. 103, pp. 287- 293 ,(1984) , 10.1677/JOE.0.1030287
M. Bläuer, P.K. Heinonen, P.M. Martikainen, E. Tomás, T. Ylikomi, A novel organotypic culture model for normal human endometrium: regulation of epithelial cell proliferation by estradiol and medroxyprogesterone acetate Human Reproduction. ,vol. 20, pp. 864- 871 ,(2005) , 10.1093/HUMREP/DEH722
Adam J Ziecik, Maria Jedlinska, Slawomir J Rzucidlo, Effect of estradiol and progesterone on myometrial LH/hCG receptors in pigs. European Journal of Endocrinology. ,vol. 127, pp. 185- 188 ,(1992) , 10.1530/ACTA.0.1270185
M. PERROT-APPLANAT, M. T. GROYER-PICARD, E. GARCIA, F. LORENZO, E. MILGROM, Immunocytochemical Demonstration of Estrogen and Progesterone Receptors in Muscle Cells of Uterine Arteries in Rabbits and Humans Endocrinology. ,vol. 123, pp. 1511- 1519 ,(1988) , 10.1210/ENDO-123-3-1511
Joan Y. Browning, P. Landis Keyes, Richard C. Wolf, Comparison of Serum Progesterone, 20α-Dihydroprogesterone, and Estradiol-17β in Pregnant and Pseudopregnant Rabbits: Evidence for Postimplantation Recognition of Pregnancy Biology of Reproduction. ,vol. 23, pp. 1014- 1019 ,(1980) , 10.1095/BIOLREPROD23.5.1014
Vaughan H. Lee, Phillip A. Fields, Rabbit relaxin: the influence of pregnancy and ovariectomy during pregnancy on the plasma profile. Biology of Reproduction. ,vol. 45, pp. 209- 214 ,(1991) , 10.1095/BIOLREPROD45.2.209
W L Kraus, B S Katzenellenbogen, Regulation of progesterone receptor gene expression and growth in the rat uterus: modulation of estrogen actions by progesterone and sex steroid hormone antagonists. Endocrinology. ,vol. 132, pp. 2371- 2379 ,(1993) , 10.1210/ENDO.132.6.8504742