Bone loss in the spondyloarthropathies: role of osteoclast, RANKL, RANK and OPG in the spondyloarthropathies.
作者： Allen P. Anandarajah , Edward M. Schwarz
DOI: 10.1007/978-1-4419-0298-6_6
关键词:
摘要: Bone loss is a common finding in the spondyloarthropathies. It may be localized and present as erosions or generalized cause osteoporosis. The pathogenesis of bone spondyloarthropathies yet to fully understood. There however increasing evidence support role for osteoclasts erosions. Similarly balance between receptor activator nuclear factor-κB ligand (RANKL) osteoprotegerin (OPG) levels thought regulate osteoclastic activity therefore inflammatory arthritides. In this chapter we will review recent literature on RANKL/OPG system various try formulate hypothesis possible mechanism group rheumatic disease.
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