Assessment of the [18F]Fluorodeoxyglucose Kinetic Model in Calculations of Myocardial Glucose Metabolism during Ischemia

摘要: The lumped constant - a term in the operational equation of Sokoloff tracer kinetic model for deoxyglucose that accounts difference transport and phosphorylation between glucose its analog, could potentially vary from normal to ischemic conditions heart. To test stability during ischemia, authors evaluated ratio extraction fraction (F-18)-fluorodeoxyglucose (FDG) glucose(a measure if there is no significant dephosphorylation FDG-6-PO/sub 4/) rate FDG-6-/sub 4/(k/sub isolated, arterially perfused interventricular septum rabbit moderate severe demand-induced reduced-flow ischemias. k/sub 4/* each four experimental were found not be significantly different value obtained nonischemic controls.