The host immune response to Clostridium difficile.

摘要: Clostridium difficile is the most common cause of nosocomial bacterial diarrhoea in Western world. Diarrhoea and colitis are caused by actions toxins A B released pathogenic strains C. difficile. Adaptive immune responses to these influence outcomes infection (CDI). Symptomless carriers toxinogenic those with a single episode CDI without recurrence show more robust antitoxin than symptomatic recurrent disease. Immune-based approaches therapy prevention have been developed using active vaccination or passive immunotherapy targeting toxins. Innate its also central pathophysiology CDI. An acute intestinal inflammatory response prominent neutrophil infiltration associated tissue injury characteristic Furthermore, inhibiting this can protect against that results from exposure animal models. Studies examining host risk factors for led validated clinical prediction tools primary Risk severe poor identified include marked elevation peripheral white blood cell count elevated creatinine. However, further work needed area guide application new disease treatment including antimicrobials as well immunization.