Compensator-based intensity-modulated radiation therapy for malignant pleural mesothelioma post extrapleural pneumonectomy.
作者： Khosrow Javedan , Craig W. Stevens , Kenneth M. Forster
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摘要: The present work investigated the potential of compensator-based intensity-modulated radiation therapy (CB-IMRT) as an alternative to multileaf collimator (MLC)-based (IMRT) treat malignant pleural mesothelioma (MPM) post extrapleural pneumonectomy. Treatment plans for 4 right-sided and 1 left-sided MPM post-surgery cases were generated using a commercial treatment planning system, XIO/CMS (Computerized Medical Systems, St. Louis, MO). We used 7-gantry-angle arrangement with 6 MV beams generate these plans. maximum required field size was 30 x 40 cm. evaluated IMRT brass compensators (.Decimal, Sanford, FL) by examining isodose distributions, dose-volume histograms, metrics quantify conformal plan quality, homogeneity. Quality assurance performed one compensator Conformal dose distributions achieved CB-IMRT all 5 cases, average target volume (PTV) coverage being 95.1% PTV receiving full prescription dose. lung V20 (volume 20 Gy) 1.8%, mean 6.7 Gy, contralateral kidney V15 0.6%. liver V30 34.0% 10% case. monitor units (MUs) per fraction 980 MUs 45-Gy prescriptions (mean: 50 1083 50-Gy 54 Gy). Post surgery, is feasible technique single isocenter. Compensator objectives safely delivered on Siemens Oncor machine (Siemens Solutions, Malvern, PA). These showed acceptably confirmed multiple measurement techniques. Not linear accelerators can deliver large-field MLC-based IMRT, but most It possible reasonable fields this conventional accelerators.
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