Cognitive function in 6- to 12-year-old offspring of women with Type 1 diabetes

摘要: Diabet. Med. 28, 845–848 (2011) Abstract Aims  Maternal diabetes is a recognized risk factor for congenital malformation, perinatal morbidity and obesity in later childhood. The aim of this study to assess the impact maternal on cognitive function offspring. Methods  Participants were 6- 12-year-old offspring women with Type 1 diabetes. All received their antenatal care delivered at one university hospital. HbA1c was monitored monthly throughout pregnancy assessed using Wechsler Intelligence Scale Children, version 4. Results  We present results 40 offspring. There no difference overall full-scale IQ compared UK normative data. However, working memory poorer than other parts Children version 4 test significantly lower data [8.4 (2.2) vs. 10.1 (3.2), P < 0.01]. found correlation between measurement digit span or any stage during (r = –0.225 0.002), gestational age delivery (r = –0.178) infant birthweight ratio (r = –0.176). relationship score hypoglycaemia episodes duration Comparing infants born before (n = 9) after 37 weeks’ gestation, non-significantly [7.9 (1.8) 8.6 (2.4)]. Discussion  These suggest have normal but memory. been unable identify specific factors. Further larger studies are required increase understanding defect modifiable