The core particle of the nucleosome

摘要: Publisher Summary A nucleosome is the fundamental repeating structural unit of chromatin; it composed two molecules core histones H2A, H2B, H3, H4, approximately superhelical turns double-stranded DNA, and linker histone H1 (H5). The existence was established in electron micrographs, name “nucleosome” coined to incorporate concept spherical nu bodies. Micrococcal nuclease limit digestion chromatin particle (NCP) as portion containing only surrounded by ∼1.75 DNA. Once became apparent that NCP could be isolated, a major goal determine crystal structure this component chromatin. This chapter discusses first report crystals attributed researchers Russia.