Cellular markers of inflammation in the airways of allergic sheep with and without allergen-induced late responses.
作者： W. M. Abraham , M. W. Sielczak , A. Wanner , A. P. Perruchoud , L. Blinder
DOI: 10.1164/AJRCCM/138.6.1565
关键词:
摘要: Allergic sheep respond to inhaled Ascaris suum antigen either with an acute bronchoconstriction alone (acute responders, AR) or both and late (dual DR). In this study, we determined if: (1) inflammatory cell composition of bronchoalveolar lavage (BAL) obtained during the response differs between DR AR; (2) difference in cells is dependent on prechallenge BAL composition; (3) drugs that block airway responses also modify inflammation. Antigen challenge caused significant immediate mean increases specific lung resistance (SRl) (n = 28) AR 14), but only had a increase SRl. There were no differences two groups total returns percentage neutrophils 7.5 8 h after challenge, 3.5-fold (p < 0.05) eosinophils. Methylprednisolone succinate (15 mg/kg intravenously) given 7) 3 antigen...
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