HLA-DPB1*0201 is associated with susceptibility to atopic myelitis in Japanese.
作者： Shinya Sato , Noriko Isobe , Satoshi Yoshimura , Yuji Kanamori , Katsuhisa Masaki
DOI: 10.1016/J.JNEUROIM.2012.07.007
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摘要: Abstract To determine the relationship between susceptibility to atopic myelitis (AM) and polymorphisms of human leukocyte antigen ( HLA )- DPB1 - DRB1 alleles, we compared each phenotype frequency 55 AM patients 367 unrelated healthy controls in Japan. The * 0201 allele was significantly more frequent than (54.5% vs. 31.9%, corrected P value = 0.0150, odds ratio = 2.564, 95% confidence interval = 1.444–4.554). Our result suggests that immunogenetic background differs from other CNS autoimmune diseases, such as multiple sclerosis neuromyelitis optica, which show distinct class II associations.
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