Haplotypes of variants in the UDP-glucuronosyltransferase1A9 and 1A1 genes.
作者： Federico Innocenti , Wanqing Liu , Peixian Chen , Apurva A. Desai , Soma Das
DOI: 10.1097/01213011-200505000-00004
关键词:
摘要: ObjectivesNine different functional UGT1A enzymes are generated from a single gene by alternative splicing, with each enzyme having unique exon 1. SN-38, the active metabolite of anticancer agent irinotecan, is metabolized both UGT1A1 and UGT1A9. We aim to characterize UGT1A9–UGT1
sci-hub.se 参考文章(19)
Christoph Köhle, Bernd Möhrle, Peter A. Münzel, Matthias Schwab, Dorothee Wernet, Osama A. Badary, Karl Walter Bock, Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians. Biochemical Pharmacology. ,vol. 65, pp. 1521- 1527 ,(2003) , 10.1016/S0006-2952(03)00074-1
Christian P. Strassburg, Susanne Kneip, Juliane Topp, Petra Obermayer-Straub, Ayse Barut, Robert H. Tukey, Michael P. Manns, Polymorphic Gene Regulation and Interindividual Variation of UDP-glucuronosyltransferase Activity in Human Small Intestine Journal of Biological Chemistry. ,vol. 275, pp. 36164- 36171 ,(2000) , 10.1074/JBC.M002180200
Hiroshi Sato, Yukihiko Adachi, Osamu Koiwai, The genetic basis of Gilbert's syndrome The Lancet. ,vol. 347, pp. 557- 558 ,(1996) , 10.1016/S0140-6736(96)91266-0
L Iyer, C D King, P F Whitington, M D Green, S K Roy, T R Tephly, B L Coffman, M J Ratain, Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. Journal of Clinical Investigation. ,vol. 101, pp. 847- 854 ,(1998) , 10.1172/JCI915
Johanna W. Lampe, Jeannette Bigler, Neilann K. Horner, John D. Potter, UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations. Pharmacogenetics. ,vol. 9, pp. 341- 349 ,(1999) , 10.1097/00008571-199906000-00009
Hugo Girard, Michael H Court, Olivier Bernard, Louis-Charles Fortier, Lyne Villeneuve, Qin Hao, David J Greenblatt, Lisa L von Moltke, Louis Perussed, Chantal Guillemette, Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver. Pharmacogenetics. ,vol. 14, pp. 501- 515 ,(2004) , 10.1097/01.FPC.0000114754.08559.27
Jean-François Gagné, Valerie Montminy, Patrick Belanger, Kim Journault, Genevieve Gaucher, Chantal Guillemette, Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Molecular Pharmacology. ,vol. 62, pp. 608- 617 ,(2002) , 10.1124/MOL.62.3.608
Ching-Shan Huang, Guo-An Luo, May-Jen Huang, Shu-Chuan Yu, Sien-Sing Yang, Variations of the bilirubin uridine-diphosphoglucuronosyl transferase 1A1 gene in healthy Taiwanese. Pharmacogenetics. ,vol. 10, pp. 539- 544 ,(2000) , 10.1097/00008571-200008000-00007
Hiroyuki Yamanaka, Miki Nakajima, Miki Katoh, Yusuke Hara, Osamu Tachibana, Junkoh Yamashita, Howard L McLeod, Tsuyoshi Yokoi, A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity. Pharmacogenetics. ,vol. 14, pp. 329- 332 ,(2004) , 10.1097/00008571-200405000-00008
Federico Innocenti, Samir D. Undevia, Lalitha Iyer, Pei Xian Chen, Soma Das, Masha Kocherginsky, Theodore Karrison, Linda Janisch, Jacqueline Ramírez, Charles M. Rudin, Everett E. Vokes, Mark J. Ratain, Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. Journal of Clinical Oncology. ,vol. 22, pp. 1382- 1388 ,(2004) , 10.1200/JCO.2004.07.173