Nonlymphoblastic Leukemia-Associated Antigens Identified by Monoclonal Antibodies

摘要: In recent years leukemia-associated markers potentially useful for diagnostic and therapeutic purposes have been defined by monoclonal antibodies. The initial perhaps most significant advance was the development of antibodies that stages differentiation T (Bradstock et al., 1980; Hansen Kung 1979; Levy McMichael Reinherz 1980) B (Nadler 1981, 1983, 1984; Stashenko Thorley-Dawson 1982) lymphocytes functionally discrete subsets (Reinherz Schlossman, 1980). These antibodies, many which were raised against leukemia cells, also delineated immunologically distinct acute lymphoblastic (ALL) (Chen 1983; Kersey 1982; LeBien Sallan More recently antibody-hybridoma technology has extended to study myeloid leukemias. Numerous antigens associated with normal malignant hematopoietic stem cells their progeny now biological clinical significance is currently under evaluation.