作者: Charles S. Goldsmith , Deborah Bell-Pedersen
DOI: 10.1016/B978-0-12-407703-4.00001-3
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摘要: The mitogen-activated protein kinase (MAPK) family of genes aids cells in sensing both extracellular and intracellular stimuli, emerging data indicate that MAPKs have fundamental, yet diverse, roles the circadian biological clock. In mammalian suprachiasmatic nucleus (SCN), MAPK pathways can function as inputs allowing endogenous clock to entrain 24h environmental cycles. also interact physically and/or genetically with components molecular oscillator, implying affect cycling Finally, rhythms pathway activation exist many different tissue types model organisms, providing a mechanism coordinately control expression tissue-specific target at proper time day. As such, it should probably not come surprise signaling clocks similar processes defects either lead same human diseases, highlighting need better define mechanisms link these two fundamental together.