Identification of Streptococcal M-Protein Cardiopathogenic Epitopes in Experimental Autoimmune Valvulitis
作者： Christine A. Kirvan , Jeffrey E. Galvin , Silvia Hilt , Stanley Kosanke , Madeleine W. Cunningham
DOI: 10.1007/S12265-013-9526-4
关键词:
摘要: The M protein of rheumatogenic group A streptococci induces carditis and valvulitis in Lewis rats may play a role pathogenesis rheumatic heart disease. To identify the epitopes M5 that produce valvulitis, synthetic peptides spanning A, B, C repeat regions contained within extracellular domain streptococcal were investigated. region NT4, NT5/6, NT7 induced similar to intact pepsin fragment protein. T cell lines from with recognized NT5/6 NT6. Passive transfer an NT5/6-specific line into naive produced characterized by infiltration CD4+ cells upregulation VCAM-1, while NT6-specific did not target valve. Our new data suggests protein-specific be important mediators rat model carditis.
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sci-hub.se 参考文章(50)
Al Bisno, The concept of rheumatogenic and non-rheumatogenic group A streptococci Streptococcal diseases and the immune response. pp. 789- 803 ,(1980)
M. Markowitz, Milton Markowitz, Angelo Taranta, Rheumatic Fever ,(1972)
J. B. Zabriskie, B. C. Seegal, K. C. Hsu, Heart-reactive antibody associated with rheumatic fever: characterization and diagnostic significance Clinical and Experimental Immunology. ,vol. 7, pp. 147- ,(1970)
Madeleine W Cunningham, Autoimmunity and molecular mimicry in the pathogenesis of post-streptococcal heart disease. Frontiers in Bioscience. ,vol. 8, ,(2003) , 10.2741/1067
Stanley Edgar Read, John B. Zabriskie, Streptococcal diseases and the immune response Academic Press. ,(1980)
Magnus Höök, Lech Switalski, Microbial Adhesion and Invasion ,(2011)
Madeleine W. Cunningham, Group A Streptococci: Molecular Mimicry, Autoimmunity and Infection Springer, New York, NY. pp. 149- 169 ,(1992) , 10.1007/978-1-4612-2924-7_13
E E Adderson, P G Shackelford, W L Carroll, M W Cunningham, A Quinn, Autoantibody germ-line gene segment encodes VH and VL regions of a human anti-streptococcal monoclonal antibody recognizing streptococcal M protein and human cardiac myosin epitopes. Journal of Immunology. ,vol. 154, pp. 4203- 4212 ,(1995)
S A Huber, M W Cunningham, Streptococcal M protein peptide with similarity to myosin induces CD4+ T cell-dependent myocarditis in MRL/++ mice and induces partial tolerance against coxsakieviral myocarditis. Journal of Immunology. ,vol. 156, pp. 3528- 3534 ,(1996)
Kellen C. Faé, Danielle Diefenbach da Silva, Sandra E. Oshiro, Ana C. Tanaka, Pablo M. A. Pomerantzeff, Corinne Douay, Dominique Charron, Antoine Toubert, Madeleine W. Cunningham, Jorge Kalil, Luiza Guilherme, Mimicry in Recognition of Cardiac Myosin Peptides by Heart-Intralesional T Cell Clones from Rheumatic Heart Disease Journal of Immunology. ,vol. 176, pp. 5662- 5670 ,(2006) , 10.4049/JIMMUNOL.176.9.5662