Prostate biopsy grading errors: a sampling problem?

摘要: Potential reasons for discordance between the Gleason score in biopsies and surgical specimens are: 1) pathological interpretation bias, 2) sampling effects. The importance of effects grading errors was examined a series where number biopsy cores obtained high. Biopsies were using technique whereby 18 directed systematically mapped out within gland. scores from matched prostatectomy compared among 28 consecutive patients with localized prostate cancer. A pooled database 10 (n = 2,687) served as baseline comparison accuracy grading. With present technique, an exact match achieved 57% cases, (PD) mean 42% (P 0.055), 1 point 93% cases 78% 0.029). Upgrading seen 35% 43% 0.19). respect to 7, 63% 0.17), upgrading 0%, 20% 0.07). data suggest significant reduction grade by minimizing effects, one that it is same order magnitude consensus pathologic evaluation. In our study, seven (25%) would have had their cancers missed altogether sextant biopsies. Sampling may contribute significantly needle biopsies, although larger study needed confirm this. methodology which adopts higher combined evaluation could potentially reduce substantially. optimal remains be determined study. Int. J. Cancer (Radiat. Oncol. Invest.) 90, 326–330 (2000). © 2000 Wiley-Liss, Inc.