Glycosylation and other PTMs alterations in neurodegenerative diseases: Current status and future role in neurotrauma.
作者： Hussein Abou-Abbass , Hadi Abou-El-Hassan , Hisham Bahmad , Kazem Zibara , Abir Zebian
关键词:
摘要: Traumatic brain injuries (TBIs) present a chief public health threat affecting nations worldwide. As numbers of patients afflicted by TBI are expected to rise, the necessity increase our understanding pathophysiological mechanism(s) as result mounts. is known augment risk developing number neurodegenerative diseases (NDs) such Alzheimer's disease (AD) and Parkinson's (PD). Hence, it rational assume that common mechanistic ground links pathophysiology NDs TBIs. Through this review, we aim identify protein-protein interactions, differential proteins expression, PTMs, mainly glycosylation, involved in pathogenesis both ND TBI. OVID PubMed have been rigorously searched studies utilized advanced proteomic platforms (MS based) systems biology tools unfold behind an attempt unveil mysterious biological processes occur postinjury. Various PTMs found be between AD, whereas no similarities PD. Phosphorylated tau protein, glycosylated amyloid precursor many other modifications appear AD. protein profiles, altered pathways critical roles interfering with their pathological condition manner similar Advancement glycoproteomic pertaining urgently needed order develop better diagnostic tools, therapies, more favorable prognoses.
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