Low rate of mother-to-child transmission of HIV-1 after nevirapine intervention in a pilot public health program in Yaoundé, Cameroon.

摘要: Objective: To determine the percentage of infected children for whom nevirapine (NVP) was used to prevent peripartum mother-to-child transmission (MTCT) HIV in Yaounde´ Cameroon. Design: The study a prospective Public Health Pilot Program covering 3-year period (January 2000–December 2002). Methods: Counseled and consenting HIV-1–positive pregnant women were given single dose NVP at onset labor. Babies 2 mg/kg syrup within first 72 hours life. NVP-treated regularly followed up examined HIV-1 infection 6–8 weeks 5–6 months through plasma viral load (VL) quantification with bDNA system. Results: One hundred twenty-three diagnosed perinatal months. Thirteen (10.6% [13/123]; 95% confidence interval 5.1–16) presented high VLs general >500000 copies/mL. Two had intermediate (between 50 3500 copies/mL) both time points. seven (87%) considered not age. Conclusions: Our results indicate that MTCT rate after administration >13% (16/123) thus demonstrating effectiveness lowering risk real-life settings. Key Words: prevention Cameroon bDNA. (authors)