Method of detecting -lactam antibiotic induced vancomycin resistant MRSA (BIVR)

摘要: Despite the fact that combination of vancomycin and a -lactam antibiotic are known to act synergistically on vancomycin-susceptible Staphylococcus aureus(VSSA), some MRSA have emerged showing antagonism a-lactam antibiotic. These called-lactam antibiotic-induced resistant (BIVR). A method based this antagonistic phenomenon has been devised detect BIVR strains. The inhibits VSSA strain but allows grow. Forty-six commercially available antibiotics induced vancomycin-resistance. Using detection method, 717 clinical isolates obtained from eight institutes throughout Japan were thus screened 6.3% these detected as when judged at 48 h.