Mucoid and Nonmucoid Burkholderia cepacia Complex Bacteria in Cystic Fibrosis Infections
作者： James E. A. Zlosnik , Paulo S. Costa , Rollin Brant , Paul Y. B. Mori , Trevor J. Hird
DOI: 10.1164/RCCM.201002-0203OC
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摘要: Rationale: Infection with Burkholderia cepacia complex (BCC) bacteria in cystic fibrosis (CF) is associated an unpredictable rate of pulmonary decline. Some BCC, but not others, elaborate copious mucoid exopolysaccharide, endowing them a gross phenotype, the clinical significance which has been described.Objectives: To determine whether there was correlation between bacterial as assessed semiquantitative manner from plate culture, and severity disease by decline lung function.Methods: We performed retrospective review 100 patients CF attending Vancouver clinics 1981 2007 analyzed function (% predicted FEV1).Measurements Main Results: Patients infected exclusively nonmucoid BCC had more rapid (annual FEV1 change, −8.51 ± 2.41%) than those (−3.01 1.09%; P < 0.05). Linear mixed-effects data modeling r...
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