Reverse micelle-based water-soluble nanoparticles for simultaneous bioimaging and drug delivery.

摘要: With special confined water pools, reverse micelles (RMs) have shown potential for a wide range of applications. However, the inherent water-insolubility RMs hinders their further application prospects, especially applications related to biology. We recently reported first successful transfer from organic media an aqueous phase without changing smart pools by hydrolysis arm-cleavable interfacial cross-linked micelles. Herein, we employed another elaborate amphiphile 1 construct new acrylamide-based water-soluble nanoparticles (ACW-NPs) under much gentler conditions. The property ACW-NPs was confirmed both Forster resonance energy (FRET) between 5-((2-aminoethyl)amino)naphthalene-1-sulfonic acid (1,5-EDANS) and benzoic acid, 4-[2-[4-(dimethylamino)phenyl]diazenyl] (DABCYL) satisfactory colloidal stability in 10% fetal bovine serum. Importantly, featured gentle synthetic strategy, pool, carboxylic acid-functionalized surface, are well suitable biological As example, fluorescent reagent 8-hydroxy-1,3,6-pyrenetrisulfonic trisodium salt (HPTS) encapsulated core simultaneously, anticancer drug gemcitabine (Gem) covalently conjugated onto surface exterior. expected, resulting multifunctional ACW-NPs@HPTS@Gem exhibits high imaging effect activity non-small lung cancer cells.