Absence of a role for interleukin-13 in inflammatory bowel disease.

摘要: IL-13 has been implicated in the pathogenesis of ulcerative colitis (UC), and may have a role animal models gut fibrosis. We studied involvement inflammation fibrosis UC Crohn's disease (CD). Intestinal biopsies anti-CD3/CD28- or anti-CD2/CD28-stimulated lamina propria mononuclear cells from CD patients control subjects were cultured, IL-13, IL-4, IL-5, IL-17A IFN-γ production was measured. Mucosal IL-13-producing characterised by flow cytometry. Gut explants strictured CD, non-strictured healthy donors cultured ex vivo, secreted IL-1β collagen mucosal activated did not differ between subjects, at least log lower than IL-17A. cells, particular natural killer T uniformly low all groups. IL-4 IL-5 undetectable culture supernatants. Explants strictures produced amounts whereas elevated. could confirm that are associated with elevated production. These data suggest an anti-IL-13 Ab would be appropriate therapeutic strategy inflammatory bowel disease.