An international survey on the impact of COVID-19 in individuals with Down syndrome

摘要: ABSTRACT Background Health conditions and immune dysfunction associated with trisomy 21 (Down syndrome, DS) may impact the clinical course of COVID-19 once infected by SARS-CoV-2. Methods The T21RS Initiative launched an international survey for clinicians or caregivers/family members on patients DS (N=1046). De-identified data collected between April October 2020 were analysed compared UK ISARIC4C hospitalized without DS. from (ISARIC4C cases=100) matched to a random set controls=400) cases in (T21RS based age, gender, ethnicity. Finding mean age was 29 years (SD=18), 73% lived their family. Similar general population, most frequent signs symptoms fever, cough, shortness breath. Pain nausea reported less frequently (p Interpretation Leading signs/symptoms risk factors severe disease are similar population. However, individuals present significantly higher rates mortality, especially 40. Funding Down Syndrome Affiliates Action, Medical Interest Group-USA, GiGi’s Playhouse, Jerome Lejeune Foundation, LuMind IDSC Matthews National Society, Task Group Intellectual Disabilities Dementia Practices.