On-line restricted access molecularly imprinted solid phase extraction of ivermectin in meat samples followed by HPLC-UV analysis.
作者： Marcela Marília de Lima , André Coutinho Vieira , Isarita Martins , Vanessa Bergamin Boralli , Keyller Bastos Borges
DOI: 10.1016/J.FOODCHEM.2015.10.082
关键词:
摘要: A new restricted access molecularly imprinted polymer coated with bovine serum albumin (RAMIP-BSA) was synthesized, characterized and used for direct analysis of ivermectin from meat samples, in a two-dimensional liquid chromatography system UV detection. Ivermectin, 4-vynilpiridine ethylene glycol dimethacrylate were employed as template, functional monomer cross-linker, respectively. BSA layer cross-linked around the polymer, resulting biocompatible chemical barrier able to eliminate about 100% protein samples. Ivermectin extracted minced samples through solvent extraction using methanol:water (70:30, v:v), extracts directly injected into system, without any other treatment. Samples, fortified 50 500 μg kg(-1), build analytical calibration curve (r=0.996). The limit quantification kg(-1). Precision accuracy presented variation coefficients, well relative errors lower than 17.0% within -18.5% 22.0%,
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