Therapeutic targeting of two-pore-domain potassium (K2P) channels in the cardiovascular system

摘要: The improvement of treatment strategies in cardiovascular medicine is an ongoing process that requires constant optimization. ability a therapeutic intervention to prevent pathology largely depends on its capacity suppress the underlying mechanisms. Attenuation or reversal disease-specific pathways has emerged as promising paradigm, providing mechanistic rationale for patient-tailored therapy. Two-pore-domain K + (K 2P ) channels conduct outward currents stabilize resting membrane potential and facilitate action repolarization. expression system polymodal current regulation suggest functional significance roles channels. Recent work focused primarily 1.1 [tandem pore domains weak inwardly rectifying channel (TWIK)-1], 2.1 [TWIK-related (TREK)-1], 3.1 acid-sensitive (TASK)-1] their role heart vessels. have been implicated atrial ventricular arrhythmogenesis setting vascular tone. Furthermore, association genetic alterations with fibrillation, cardiac conduction disorders pulmonary arterial hypertension demonstrates relevance disease. function, clinical are summarized present review, options emphasized.