Next-generation sequencing for endocrine cancers: Recent advances and challenges.

摘要: Contemporary molecular biology research tools have enriched numerous areas of biomedical that address challenging diseases, including endocrine cancers (pituitary, thyroid, parathyroid, adrenal, testicular, ovarian, and neuroendocrine cancers). These placed several intriguing clues before the scientific community. Endocrine pose a major challenge in health care despite considerable attempts by researchers to understand their etiology. Microarray analyses provided gene signatures from many cells, tissues, organs can differentiate healthy states diseased ones, even show patterns correlate with stages disease. data also elucidate responses tumors therapeutic treatments. The rapid progress next-generation sequencing methods has overcome initial challenges these technologies, advantages over microarray techniques enabled them emerge as valuable aids for clinical resea...