Evidence for a Proatherogenic Biochemical Phenotype in Beta Thalassemia Minor and Intermedia

摘要: The purpose of this study was to focus on pathophysiological mechanisms linking β-thalassemia intermedia (β-TI) and minor (β-TMI) with cardiovascular risk. Iron status, prooxidant-antioxidant balance lipid profiles in serum, content peripheral blood mononuclear cells (PBMCs) were evaluated 20 β-TMI subjects, 22 β-TI patients 30 nonthalassemic donors. mRNA levels some genes involved the regulation iron cholesterol metabolism also determined. In β-TMI, serum iron, ratio, transferrin saturation erythropoietin higher, while hepcidin lower compared controls. Hepcidin interleukin-1α found be reduced β-TI- β-TMI-PBMCs, those tumor necrosis factor alpha increased. A reduction high-density lipoprotein an accumulation neutral lipids coupled increased acetyl-coenzyme A:cholesterol acyltransferase decreased ester hydrolase PBMCs observed Taken together, these findings provide experimental support for idea that not only but have a proatherogenic biochemical phenotype which may contribute increase their disease