Immunogenicity of β-cells for autologous transplantation in type 1 diabetes.
作者： Christian Schuetz , James F. Markmann
DOI: 10.1016/J.PHRS.2015.03.003
关键词:
摘要: The success of clinical islet transplantation calls for a broader application this curative treatment type 1 diabetes mellitus. toxicity immunosuppression, limited organ donor supply and high procedural costs are deterrents to expand therapy patients with uncomplicated diabetes. use pancreatic β-cell like cells derived from the patient's own induced pluripotent (iPSC) holds potential overcome these barriers. In review, we discuss practicality regenerative medicine approach existing evidence regarding true immunogenicity iPSC cells.
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