Plasmacytoid dendritic cells mediate oral tolerance.
作者： Anne Goubier , Bertrand Dubois , Hanane Gheit , Grégoire Joubert , Florence Villard-Truc
DOI: 10.1016/J.IMMUNI.2008.06.017
关键词:
摘要: Summary Oral tolerance prevents oral sensitization to dietary antigens (Ags), including proteins and haptens, development of delayed-type hypersensitivity (DTH) responses. We showed here that plasmacytoid dendritic cells (pDCs) prevented T cell priming were responsible for systemic CD4 + CD8 T cell-mediated DTH responses induced by Ag feeding. Systemic depletion pDCs induction antigen Transfer Ag-loaded liver naive recipient mice Ag-specific suppression protein hapten, respectively. Liver is a site presentation, appeared induce anergy or deletion T cells in the relatively rapidly via T cell-independent mechanism. These data demonstrate relies on presentation pDC suggest could represent key therapeutic target intestinal inflammatory diseases.
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