Neurotrophin-3 reverses nerve conduction velocity deficits in streptozotocin-diabetic rats.

摘要: The ability of neurotrophin-3 (NT-3) to reverse established nerve disorders was investigated in the peripheral neuraxis streptozotocin-diabetic rats. Sciatic sensory and motor conduction velocity deficits after 2 months diabetes were completely normalized by one further month treatment with either NT-3 or insulin. None these changes associated altered mean axonal caliber sciatic nerve. In dorsal ventral roots, significantly decreased 8 weeks (both P < 0.05). Subsequently, insulin, but not NT-3, increased age-matched control values. also without effect on significant 0.05) decrease phosphorylated heavy neurofilament (NFH) subunits seen roots 12 week diabetic sural nerve, attenuated a maturation-associated increase over first diabetes, induced atrophy between that ameliorated both insulin treatment. Reductions tendency for elevation NFH levels large fibers ratio nonphosphorylated NT-3. These data demonstrate corrects rats manner independent this Further, although decreases subunit phosphorylation spinal reversal nerves may involve NT-3-mediated normalization aberrant phosphorylation.