Persistence of Immunity to Varicella in Children with Leukemia Immunized with Live Attenuated Varicella Vaccine

摘要: To determine the safety and efficacy of varicella vaccine, we studied 437 children in remission from leukemia who were immunized with live attenuated virus. Three hundred one patients received two doses vaccine 136 a single dose 1 10 lots manufacturers. The have been followed for an average three years (range, to six). Seroconversion occurred 88 percent after first 98 or doses. proportions seronegative one, three, five 20, 25, 30 percent, respectively, little change over time geometric mean titers specific antibody (6.3, 6.5, 5.7, respectively). Chickenpox has documented 36 vaccinated (8 percent) had 3 640 vesicles (mean, 100), mild illness, no complications. Of 83 exposed within their families, 11 chickenpox; attack rate was 14 among seropositive patients, 29 patients). There relation between since vaccination either severity breakthrough illness. Two appeared be more effective than dose. 372 receiving maintenance chemotherapy when immunized, 149 (40 rash, which treated acyclovir 16 (4 became severe febrile illness 4. These reactions not fatal all associated lots, use discontinued. We conclude that leukemia, is safe induces immunity chickenpox persists years.