Passive immunization with monoclonal antibody against a 70-kDa putative adhesin of Sporothrix schenckii induces protection in murine sporotrichosis.
作者： Rosana C Nascimento , Noeli M Espíndola , Rafaela A Castro , Pedro AC Teixeira , Carla V Loureiro y Penha
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摘要: Cell-mediated and innate immunity are considered the most important mechanisms of host defense against fungus infections. However, recent studies demonstrated that specific antibodies show different degrees protection mycosis. In a previous study, antigens secreted by Sporothrix schenckii induced humoral response in infected animals, mainly 70-kDa molecule, indicating possible participation to this antigen infection control. present an IgG1 mAb was produced glycoprotein S. order better understand effect passive immunization mice with schenckii. Results showed significant reduction number CFU organs when injected before during infection. Similar results were observed T-cell-deficient used. Moreover, second schedule treatment, after established, again we associated increase IFN-γproduction. Also, is shown be putative adhesin on surface fungus. conclusion, report for first time protective antibody
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A Shiraishi, K Nakagaki, T Arai, Experimental sporotrichosis in congenitally athymic (nude) mice. Journal of the Reticuloendothelial Society. ,vol. 26, pp. 333- ,(1979)
C L Dickerson, R L Taylor, D J Drutz, Susceptibility of congenitally athymic (nude) mice to sporotrichosis. Infection and Immunity. ,vol. 40, pp. 417- 420 ,(1983) , 10.1128/IAI.40.1.417-420.1983
L M Oda, C F Kubelka, C S Alviano, L R Travassos, Ingestion of yeast forms of Sporothrix schenckii by mouse peritoneal macrophages. Infection and Immunity. ,vol. 39, pp. 497- 504 ,(1983) , 10.1128/IAI.39.2.497-504.1983
Marcio L. Rodrigues, Luiz R. Travassos, Kildare R. Miranda, Anderson J. Franzen, Sonia Rozental, Wanderley de Souza, Celuta S. Alviano, Eliana Barreto-Bergter, Human antibodies against a purified glucosylceramide from Cryptococcus neoformans inhibit cell budding and fungal growth. Infection and Immunity. ,vol. 68, pp. 7049- 7060 ,(2000) , 10.1128/IAI.68.12.7049-7060.2000
K. S. S. Fernandes, A. L. J. Coelho, L. M. Lopes Bezerra, C. Barja-Fidalgo, Virulence of Sporothrix schenckii conidia and yeast cells, and their susceptibility to nitric oxide Immunology. ,vol. 101, pp. 563- 569 ,(2000) , 10.1046/J.1365-2567.2000.00125.X
Evandro A Rivitti, ValÉria Aoki, Deep fungal infections in tropical countries. Clinics in Dermatology. ,vol. 17, pp. 171- 190 ,(1999) , 10.1016/S0738-081X(99)00010-3
Osana C. Lima, Camila C. Figueiredo, José O. Previato, Lucia Mendonça-Previato, Verônica Morandi, Leila M. Lopes Bezerra, Involvement of Fungal Cell Wall Components in Adhesion of Sporothrix schenckii to Human Fibronectin Infection and Immunity. ,vol. 69, pp. 6874- 6880 ,(2001) , 10.1128/IAI.69.11.6874-6880.2001
T. Tachibana, T. Matsuyama, M. Mitsuyama, Involvement of CD4+ T cells and macrophages in acquired protection against infection with Sporothrix schenckii in mice Medical Mycology. ,vol. 37, pp. 397- 404 ,(1999) , 10.1046/J.1365-280X.1999.00239.X
D M O'Riordan, J E Standing, K Y Kwon, D Chang, E C Crouch, A H Limper, Surfactant protein D interacts with Pneumocystis carinii and mediates organism adherence to alveolar macrophages. Journal of Clinical Investigation. ,vol. 95, pp. 2699- 2710 ,(1995) , 10.1172/JCI117972
María J. Sevilla, Beatriz Robledo, Aitor Rementeria, María D. Moragues, José Pontón, A fungicidal monoclonal antibody protects against murine invasive candidiasis. Infection and Immunity. ,vol. 74, pp. 3042- 3045 ,(2006) , 10.1128/IAI.74.5.3042-3045.2006