Nephroprotective potential of selenium and taurine against mercuric chloride induced nephropathy in rats.
作者： Fatma E. Agha , Eman R. Youness , Mai M. H. Selim , Hanaa H. Ahmed
DOI: 10.3109/0886022X.2014.890012
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摘要: AbstractThe study was aimed to estimate whether pre-treatment with sodium selenite or taurine would reverse kidney damage induced by intraperitoneal injection of mercuric chloride in rats. Animals were divided into six groups: (1) control group; (2) (3) (4) HgCl2 (5) pretreated (6) group. The results demonstrated that causes significant enhancement serum malondialdehyde (MDA), creatinine, N-acetyl-beta-d-glucosaminidase (NAG), cystatin C, nephrin and interleukin 6 (IL-6) levels accompanied reduction nitric oxide (NO) level. Pretreatment produces depletion MDA, NAG, IL-6 concomitant elevation NO level as compared pathological alterations the kidney. ultrastructural investigation renal cortex HgCl2-administered group revealed glome...
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