Melanoma and Other Skin Cancers

摘要: Skin cancers are the most prevalent of all malignancies with 50% Americans reaching age 65 expected to develop one form skin cancer in their lifetimes. The two common forms cancer, basal cell carcinoma and squamous (the so-called nonmelanoma cancers), from keratinocytes, have a low tendency metastasize less deadly. In contrast, melanomas melanocytes follow an aggressive clinical course account for majority deaths. recent years seen giant leap our understanding molecular events that underlie development progression both melanoma cancers. This has turn led targeted therapeutic agents specifically inhibit oncogenic mutations drive these this review, we outline latest knowledge on etiology, biomarkers, prognostic classification We discuss detail how comprehensive genetic analysis number distinct subgroups being described review literature preclinical personalized therapy strategies finally look future describe in-depth mutational profiling patients’ tumors will yield important diagnostic information help guide choice therapy.