Utility of 18F-FDG PET with a Semi-Quantitative Index in the Detection of Sarcomatous Transformation in Patients with Neurofibromatosis Type 1

摘要: Background Malignant peripheral nerve sheath tumors (MPNSTs) are a serious complications of neurofibromatosis type 1 associated with poor prognosis and deeper lesions can be difficult to diagnose. 18-FDG PET improves the detection malignancies. However, criteria for malignancy, notably SUVmax threshold, not standardized. Therefore, aim study was evaluate semi-quantitative index reproducible MPNST FDG PET. Methods It is multicenter retrospective conducted between 2000 2012. All patients NF1 referred suspected underwent PET. Since available until 2004 in our centers, we had settle method used at that time, uptake ratio tumor normal liver (T/L ratio) 1.5 as cut-off malignancy. When dedicated became available, analysis images remained, along SUVmax. Results 113 145 were included. assessment revealed 65 T/L >1.5 among these, 40 MPNSTs. 80 classified non-suspicious, 79 benign. The negative predictive value (NPV) 98,8% positive 61,5%. likelihood (LR) 4,059, LR 0,032 97% sensitivity 76% specificity. Conclusions This study, which largest published, confirms utility detecting NF1-associated A index, 1.5, allowed sensitive specific differentiation malignant from benign better than SUVmax. there strong suspicion This analytical simple SUVmax, but more sensitive, non-user-dependent.