Intravascular lymphomatosis (malignant angioendotheliomatosis). A B-cell neoplasm expressing surface homing receptors.

摘要: Abstract We report the clinical and immunohistochemical features of six cases intravascular lymphomatosis. All patients presented with symptoms referable to central nervous system (CNS) involvement. In two patients, diagnosis was made on brain biopsy specimens. remaining four cases, at autopsy. Three autopsied had focal extravascular lymphoma, diffuse large cell type. all five tested, stains paraffin-embedded sections confirmed lymphoid nature malignant cells. Stains frozen in one case, tissue other demonstrated B-lymphocyte lineage. electron microscopy tumor three tested expressed Hermes 3-defined homing receptor antigen lacked peanut agglutinin receptors. Our results are consistent reports confirming so-called angioendotheliomatosis. limited analysis surface molecules suggests that expression for high endothelial venules is not itself responsible unusual location these