Left Ventricular Electromechanical Mapping to Assess Efficacy of phVEGF165 Gene Transfer for Therapeutic Angiogenesis in Chronic Myocardial Ischemia
作者： Peter R. Vale , Douglas W. Losordo , Charles E. Milliken , Michael Maysky , Darryl D. Esakof
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摘要: Background—NOGA left ventricular (LV) electromechanical mapping (EMM) can be used to distinguish among infarcted, ischemic, and normal myocardium. We investigated the use of percutaneous LV EMM assess efficacy myocardial gene transfer (GTx) naked plasmid DNA encoding for vascular endothelial growth factor (phVEGF165), administered during surgery by direct injection in patients with chronic ischemia. Methods Results—A total 13 consecutive (8 men, mean age 60.1±2.3 years) stable angina due angiographically documented coronary artery disease, all whom had failed conventional therapy (drugs, PTCA, and/or CABG), were treated phVEGF165 via a minithoracotomy. Foci ischemic myocardium identified on preserved viability associated an impairment linear local shortening. Myocardial viability, defined unipolar bipolar voltage recordings ≥5 ≥2 mV, respectively, did not chan...
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