Genealogies in Growing Solid Tumors

摘要: Over the past two decades, theory of tumor evolution has largely focused on selective sweeps model. According to this theory, tumors evolve by a succession clonal expansions that are initiated driver mutations have fitness advantage over resident types. A 2015 study colon cancer Sottoriva et al suggested an alternative evolution, so-called Big Bang model, in which all necessary acquired before expansion began, and evolutionary dynamics within expanding population predominantly neutral. In paper, we will describe simple mathematical model inspired work Hallatschek Nelson (2009) makes quantitative predictions about spatial patterns genetic variability. While some success matching observed dimensions, it fails miserably three dimensions. Despite failure, think analyzed here be useful first step building accurate