Brain prostaglandins mediate the bombesin-induced increase in plasma levels of catecholamines
作者： Yasunobu Okuma , Kunihiko Yokotani , Yoshitsugu Osumi
DOI: 10.1016/0024-3205(96)00445-6
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摘要: Abstract Intracerebroventricular (i.c.v.) administration of bombesin (0.1, 1.0, 10.0 nmol/animal) in urethane-anesthetized rats induced long-lasting and dose dependent increases plasma levels adrenaline noradrenaline. These effects were inhibited by i.c.v. pretreatment with indomethacin (50–500 μg/animal), while the same intravenous route was without effect. The bombesin-induced catecholamines also diclofenac (100–500 a cyclooxygenase inhibitor other than indomethacin. I.c.v. thyrotropin releasing hormone (TRH) (10 noradrenaline, however, these not modified present results suggest that are probably due to prostaglandins synthetized brain this neuropeptide. Furthermore, it is likely always involved central activation sympatho-adrenomedullary system neuropeptides.
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