Pharmacokinetics of quercetin-loaded nanodroplets with ultrasound activation and their use for bioimaging.

摘要: Bubble formulations have both diagnostic and therapeutic applications. However, research on nanobubbles/nanodroplets remains in the initial stages. In this study, a nanodroplet formulation was prepared loaded with novel class of chemotherapeutic drug, ie, quercetin, to observe its pharmacokinetic properties ultrasonic bioimaging specific sites, namely abdominal vein bladder. Four parallel groups were designed investigate effects ultrasound nanodroplets pharmacokinetics quercetin. These quercetin alone, triggered ultrasound, quercetin-encapsulated nanodroplets, encapsulated ultrasound. Spherical vesicles mean diameter 280 nm formed, completely within. vivo imaging confirmed that could be treated by The results indicate 5-minute serum concentration, area under concentration–time curve, elimination half-life, clearance significantly enhanced or without