Comparison of two nonlinear models for fitting saccadic eye movement data

摘要: Saccadic eye movements are rapid shifts in the direction of gaze which being studied increasingly for clinical and pharmacological purposes. The evaluation relationship between amplitude peak velocity these ocular (the so-called 'main sequence' plot) is particularly useful characterising saccade pattern individual patients. This nonlinear tends to achieve an asymptote high values amplitude. Since a standard parametrisation main sequence based on specific mathematical models has not yet been achieved, present study two simple Michaelis-Menten equation exponential proposed together with their implementation microcomputer. Two microcomputer programs described estimate model parameters from experimental data patients using weighted least-squares fit. procedures have tested compared series 23 healthy volunteers. following results (mean +/- S.D.) were obtained: model. Km (degrees) = 31.2 7.7, Vmax (degrees/s) 841.0 165.5, root-mean-squared error(%) 6.0 1.6; K 23.4 4.6, 578.0 97.4, 5.4 1.6. techniques provided similar indices intra-individual variability 4 In conclusion, our methods can be regarded as but efficient tools facilitating research movements.